Microtubules (MTs) are protein filaments found in all eukaryotic cells which are crucial for many cellular processes including cell movement, cell differentiation, and cell division, making them a key target for anti-cancer treatment. In particular, it has been shown that at low dose, MT targeted agents (MTAs) may induce an anti-migratory effect on cancer and endothelial cells, leading to new prospects in cancer therapy.
While cells typically tend to spread their cytoplasm in a flat and thin lamellipodium when moving on a flat substrate, it is widely observed that the cytoplasm has a compact shape in micro-channels, tending to fulfill the cross-section of the microchannel. We propose a minimal mathematical model for a 2D test case which describes the cell lamellipodium deformations when confined in a channel.
We introduce a new non-overlapping optimized Schwarz method for fully anisotropic diffusion problems. Optimized Schwarz methods take into account the underlying physical properties of the problem at hand in the transmission conditions, and are thus ideally suited for solving anisotropic diffusion problems.
Internal shear layers generated by the longitudinal libration of the inner core in a spherical shell rotating at a rate Ω * are analysed asymptotically and numerically. The forcing frequency is chosen as √ 2Ω * such that the layers issued from the inner core boundary at the critical latitude in the form of concentrated conical beams draw a simple rectangular pattern in meridional cross-sections.
Global food demand is rising, pushed by growing world population and dietary changes in developing countries. This encourages farmers to increase crop production which, in turn, increases worldwide demand for agricultural land and the pressure on tropical forests. With a possible doubling of world food demand by 2050, this pressure is not likely to decrease in the next decades.
Background An Escherichia coli (E. coli) pathotype with invasive properties, first reported by Darfeuille-Michaud and termed adherent-invasive E. coli (AIEC), was shown to be prevalent in up to half the individuals with Crohn’s Disease (CD), suggesting that these bacteria could be involved in the pathophysiology of CD.
Methyl-and dimethyl-ethylenedithio-tetrathiafulvalene ortho-diamide donors Me-EDT-TTF(CONH2)2 (1a) and DM-EDT-TTF(CONH2)2 (1b) have been prepared by the direct reaction of the corresponding diester precursors with aqueous ammonia solutions. The neutral (rac)-1a, (S)-1a and (S,S)-1b donors have been characterized by single crystal X-ray diffraction.
Le chômage engendre-t-il le chômage ? Le débat oppose les tenants d’une hétérogénéité pure, éventuellement inobservable du statisticien, aux partisans d’une véritable relation de dépendance des probabilités de sortie vis-à-vis de la durée de l’épisode de chômage.
In this work, we consider the momentum transport of a incompressible fluid in a like Beavers and Joseph (1967) system. For this purpose, in the context of the volume averaging method, we use a one-domain approach (ODA). Thus, the momentum generalized transport equations (GTE), which are written in terms of position-dependent effective medium coefficients, are valid everywhere in the system and contains two Brinkman corrections in addition to a Darcy’s term.
We revisit fertility analysis in Tunisia by examining family interference in birth control through: woman's marriage age, post-marriage delay in the first use of contraception, past and current contraceptive use, and choice of the birth control methods. Using data from the 2001 PAP-FAM Tunisian survey, we find that the significant effects of covariates arise and vanish across stage-specific equations as women progress in their lifecycle.